TOXICOLOGICAL SAFETY PROFILE ANTI-TUBERCULOSIS DRUG «RIFABUTIN» WITH PROLONGED ADMINISTRATION UNDER EXPERIMENTAL CONDITIONS

Effects of prolonged administration of anti-cumulus

Mice were passively immunized over 6 weeks with contraceptive doses of an anti-cumulus oophorus antibody preparation. The persistence of oestrus, accompanied by complete inhibition ofconception, was observed throughout treatment. After cessation of treatment, fertility was restored within 2 weeks. Histological examination did not reveal any depletion of the ovarian oocyte stock. These results w...

Molecular detection of rifabutin-susceptible Mycobacterium tuberculosis.

Rapid assays are still needed to detect rifabutin (RFB) susceptibility for proper tuberculosis treatment. To assess the use of the GenoType MTBDRplus assay and subsequent rpoB gene sequencing on detection of RFB susceptibility, we analyzed 800 multidrug-resistant Mycobacterium tuberculosis isolates, and 13% (104/800) were RFB susceptible. Of the 104 RFB-susceptible isolates, 71 (68.3%) isolates...

Bilateral uveitis associated with concurrent administration of rifabutin and nelfinavir

Rifabutin-associated uveitis has been recognized as a dosage-dependent side effect. Previous studies have reported that clarithromycin or fluconazole may elevate concentrations of rifabutin through inhibition of metabolism through the cytochrome P-450 pathway. Nelfinavir is a protease inhibitor widely used in the treatment of human immunodeficiency virus (HIV) infection. The interactions betwee...

Toxicological Profile for Zinc

Toxicological Profile for Aluminum